Ojji DB, et al. - Given the high prevalence of hypertension among black African patients who usually need ≥ 2 medications for blood-pressure control, researchers investigated the most effective two-drug combination currently available for blood-pressure control via performing this randomized, single-blind, three-group trial conducted in six countries in sub-Saharan Africa. The study sample consisted of 728 black patients with uncontrolled hypertension (≥ 140/90 mmHg while the patient was not being treated or taking only one antihypertensive drug) who were randomized to receive a daily regimen of 5 mg of amlodipine plus 12.5 mg of hydrochlorothiazide, 5 mg of amlodipine plus 4 mg of perindopril, or 4 mg of perindopril plus 12.5 mg of hydrochlorothiazide for 2 months. Outcomes suggested a higher efficacy of amlodipine plus either hydrochlorothiazide or perindopril vs perindopril plus hydrochlorothiazide for lowering blood pressure levels at 6 months in black patients in sub-Saharan Africa.