Saleh OA, et al. - This study was intended to compare characteristics, clinical outcomes and complication profiles of a cohort of patients undergoing 27-gauge vs 23-gauge vitrectomy surgery at a tertiary medical center in the Middle East. A retrospective comparative study was conducted to include indication-matched patients who had undergone 27-gauge vs 23-gauge pars plana vitrectomy for a set of predetermined diagnoses. Researchers examined data including indications for surgery, clinical exams, visual outcomes, and complications. They compared 22 patients who had 27-gauge pars plana vitrectomy with 44 patients who had 23-gauge surgery for matched indications by a single retina surgeon. The rate of hypotony and the requirement for sclerotomy suturing were significantly less in the 27-gauge group vs the 23-gauge group in this cohort of patients undergoing vitrectomy at a tertiary eye center. In both study groups, surgical outcomes were similar. In selected vitreoretinal diseases, the use of the novel 27-gauge instrument system is beneficial and seems comparable to the widely applied 23-gauge system.