Wu D, Griffith JF, Lam SHM, et al. - This study was undertaken to compare the bone structure and microstructure in the metacarpal head (MCH) between patients with psoriatic arthritis (PsA) and healthy controls by high-resolution peripheral quantitative CT (HR-pQCT), and to determine factors correlated with bone loss in PsA patients. Researchers enrolled a total of 62 PsA patients without joint destruction and 62 age-, gender-, and body mass index–matched healthy subjects who had undergone HR-pQCT imaging of the second and third MCH (MCH 2&3). They recorded the number and volume of bone erosion and enthesiophytes, as well as volumetric bone mineral density (vBMD) and microstructure at the MCH 2&3. The correlation of demographic and disease-specific variables with compromised bone structure and microstructure in PsA were ascertained using correlation analysis and multivariable linear regression models. Compared with healthy control, PsA patients had a higher burden of bone damages (erosions and enthesiophytes) and trabecular bone loss at the MCH. Among these patients, inflammation contributed to the deterioration in trabecular microstructure.