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Comparison of a theoretically driven cognitive therapy (the Feeling Safe Program) with befriending for the treatment of persistent persecutory delusions: A parallel, single-blind, randomized controlled trial

The Lancet Psychiatry Jul 29, 2021

Freeman D, Emsley R, Diamond R, et al. - Via this parallel, single-blind, randomized controlled trial, researchers sought to examine if a new theoretically driven cognitive therapy (the Feeling Safe Program) would aid in achieving large decreases in persecutory delusions, above non-specific effects of therapy. In addition, they examined treatment effect mechanisms. Recruitment was performed of 130 patients with persecutory delusions (78 [60%] men; 52 [40%] women, mean age 42 years [SD 12·1, range 17–71]; 86% White, 9% Black, 2% Indian; 2·3% Pakistani; 2% other). Random allocation of 64 patients was done to the Feeling Safe Program and 66 patients to befriending. Findings suggest correlation of the Feeling Safe Program with a significant decrease in persistent persecutory delusions when compared with befriending. This work reported the largest treatment effects observed for patients with persistent delusions. Per outcomes, the Feeling Safe Program could become the recommended psychological therapy in clinical services for persecutory delusions.

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