Xie Y, Jun D, Thomas L, et al. - Via performing this systematic review and meta-analysis, researchers investigated the evidence for altered central pain processing in people with nontraumatic neck pain and determined the correlation among central pain processing, demographics, and pain-related characteristics. Of the 26 identified eligible studies, they included 25 in meta-analysis. Findings from meta-analysis revealed mechanical hyperalgesia at remote nonpainful sites in the full sample (sample size [n] = 1,305, SMD = −0.68) and in the subgroup with moderate/severe disability (n = 165, SMD = −0.86; moderate-quality evidence). In metaregression, there was negative correlation between remote mechanical hyperalgesia and age. They identified very low- to low-quality evidence suggesting remote cold and heat hyperalgesia and dysfunctional conditioned pain modulation. This review suggests that people with nontraumatic neck pain exhibit altered central pain processing and this alteration may be linked with disability levels and age.