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Comparative study of long-term graft survival between penetrating keratoplasty and deep anterior lamellar keratoplasty

American Journal of Ophthalmology Dec 02, 2020

Arundhati A, Chew MCY, Li L, et al. - Researchers conducted this retrospective clinical cohort study to compare long-term graft survival between penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK). All consecutive primary grafts of DALKs (n = 362) and PKs (n = 307) done for optical indications in a tertiary eye centre from the ongoing prospective Singapore Corneal Transplant Study. Data reported that the survival rate for PK was 94.4%, 80.4% and 72.0% at 1, 5 and 10 years; and 95.8%, 93.9% and 93.9% at 1, 5 and 10 years for DALK. Ten-year graft survival for primary DALK was higher than PK for corneal pathologies with functional endothelium. Primary DALK results in fewer postoperative complications and lower rates of grafting rejection and failure. This research strengthens the case in favor of where possible, performing DALK over PK.

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