Wanichwecharungruang B, Kongthaworn A, Wagner D, et al. - A comparative cross-sectional study was performed to compare lamina cribrosa thickness (LCT) of primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG) utilizing the enhanced depth-imaging mode of the Heidelberg Spectralis spectral-domain optical coherence tomography (EDI-OCT). Thirty-four patients with PACG, 38 with POAG, and 62 controls were enrolled, testing only one eye of each participant. Using EDI-OCT, lamina cribrosa thickness was determined at the center of the optic nerve head. Glaucomatous eyes had a thinner LCT compared with controls, and maximum IOP was inversely associated with the LCT. The maximum IOP and thinner LCT were higher for PACG eyes than for POAG eyes. EDI-OCT emphasizes the pressure-dependent glaucoma mechanism of lamina cribrosa deformation in living eyes and the higher IOP-loaded stress that contributes to a higher lamina cribrosa strain.