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Comparative study of fertility parameters in vitrified human spermatozoon in the presence or absence of EmbryORP: A novel antioxidant

Andrologia Feb 12, 2021

Coria‐Gómez CR, Torres‐Rodríguez P, Villar‐Muñoz LG, et al. - In this study, researchers explored a novel antioxidant called EmbryORP in a vitrification protocol and compared eight fertility parameters: motility, viability, morphology, concentration, the semen pH, the oxidation‐reduction potential (ORP), the spontaneous acrosomal reaction, and the mitochondrial membrane potential (MMP), in the presence or absence of EmbryORP. They examined 20 samples from healthy human sperm donors and found that the antioxidant significantly reduced the semen pH as well as the MMP and the ORP affecting the balance of ROS. According to the outcomes, our work opens new perspectives on how to improve cryopreservation media. Thus, they recommend exploring the EmbryORP potential benefit by decreasing its concentration or changing the exposure time during the cryopreservation protocol.

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