Oun AAA, et al. - Researchers conducted this comparative split-neck intervention study to determine whether fractional‐ablative CO ₂ laser or retinoic acid (5%) peel is the more effective and safe choice for acanthosis nigricans (AN) treatment. Twenty Egyptian cases with neck‐AN were enrolled in this study, and each case received four sessions, 2 weeks apart, of both fractional CO ₂ laser on the right half of the neck and retinoic acid peel on the left half. Cases were evaluated by a scoring system: Acanthosis Nigricans Area and Severity Index score, two blinded dermatologists, and dermoscopically pre and one‐month post‐treatment. For neck‐AN treatment, fractional CO ₂ laser and retinoic acid peel are considered effective modalities. The fractional CO ₂ laser, on the other hand, was more effective.