Hernandes RT, Hazen TH, dos Santos LF, et al. - From diarrheal patients in Brazil, atypical EPEC (aEPEC) is one of the most frequent diarrheagenic Escherichia coli pathotypes isolated. Researchers here investigated the phylogeny and the gene content of Brazilian atypical enteropathogenic Escherichia coli (aEPEC) genomes compared with a global aEPEC collection. This study is identified to be the first work on this topic. They compared 106 sequenced Brazilian aEPEC with 221 aEPEC obtained from other geographic origins using single nucleotide polymorphism (SNP)-based phylogenomic analysis was used to. In addition, they used Large-Scale BLAST Score Ratio to ascertain the shared vs unique gene content of the aEPEC studied. Brazilian aEPEC genomes were identified in previously characterized EPEC/EHEC phylogenomic lineages. The approach led to the identification of five novel EPEC phylogenomic lineages, designated EPEC11 to EPEC15. Further, it was noted that the Brazilian aEPEC genomes more frequently exhibit virulence genes, such as espG2, espT and espC, demonstrating potential differences in the virulence repertoire of this pathogen in Brazil.