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Comparative functional outcomes after corneal crosslinking using standard, accelerated, and accelerated with higher total fluence protocols

Cornea Mar 09, 2019

Lang PZ, et al. - Using standard protocol and accelerated protocols in patients with progressive keratoconus, authors examined 93 eyes to evaluate the relative 12-month corneal crosslinking (CXL) functional outcomes. They observed 35 eyes with standard [3 mW/cm2 for 30 minutes, 5.4 J/cm2 (S3/30-CXL)], 29 eyes with accelerated with equivalent total irradiance [9 mW/cm2 for 10 minutes, 5.4 J/cm2 (A9/10-CXL)], and 29 eyes with accelerated with increased total irradiance [30 mW/cm2 for 4 minutes, 7.2 J/cm2 (A30/4-CXL)]. They recorded improvement in K Max, CDVA, and other variables with comparable functional consequences for each despite greater change in keratoconus indices after S3/30-CXL with all the 3 protocols. They found overall poorer correlations between change in measured variables and CDVA. But, an association of K Mean, central keratoconus index, and anterior asphericity was noted with CDVA.
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