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Comparative analyses of clinical features, histopathology, and CD123 immunohistochemistry of oral lupus erythematosus, lichen planus, and other lichenoid lesions

Dermatology Aug 14, 2021

Chanprapaph K, Pomsoong C, Tankunakorn J, et al. - This retrospective study demonstrates that clinicopathological features are somewhat different between oral lupus erythematosus (OLE), oral lichen planus (OLP), as well as other oral lichenoid lesions (OLLs), however, a significant overlap exists. There is a diagnostic implication of the quantity and distribution pattern of CD123 immunohistochemical staining in distinguishing OLE from OLP and other OLLs.

  • Total 70 patients were included; 12 had OLE, 39 had OLP, and 19 had other OLLs.

  • OLE patients more commonly presented with red macules, telangiectases, and discoid plaques, while OLP patients were typified by reticulated patches.

  • Histological analysis showed presence of mucosal atrophy, basal vacuolization, and perivascular infiltrate in OLE, whereas mucosal hyperplasia, hypergranulosis, and compact orthokeratosis were present in OLP specimens.

  • A histologic characteristic that favored other OLLs over OLE and OLP was mucosal spongiosis.

  • OLE, vs OLP, had a higher median number of total CD123+ plasmacytoid dendritic cells (PDCs) in the mucosal-submucosal junction, the superficial perivascular area, and the superficial and deep perivascular areas.

  • In both OLE and OLP, significantly more numerous CD123+ PDCs were detected in all of the abovementioned areas, compared with other OLLs.

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