Drivelegka P, et al. - Researchers studied the incidence of comorbidities at the time of first diagnosis of gout vs matched population controls, overall and by sex. They also evaluated the crude and age-standardized pervasiveness of these comorbidities in men and women with gout at first diagnosis. Findings suggested a significant increase in the occurrence of most comorbidities at first diagnosis of gout in both sexes. At diagnosis, women were older and presented with most comorbidities, including obesity and diuretic use, which are factors that increase serum urate. When starting and optimizing urate-lowering therapy, this needs to be taken into account. When standardizing for age, these sex differences were attenuated. The cardiovascular diseases occurred more frequently in men.