Giussani G, Bianchi E, Beretta S, et al. - In this cohort study, researchers focused on the frequency, types, and mechanisms of comorbidities in individuals suffering from epilepsy, and also intended to verify their link with disease features as well as outcome. Total 1006 patients were included, with at least one comorbidity present in 266 (26.4%). Developmental/perinatal (7.5% of cases), psychiatric (6.2%), cardiovascular (5.3%), and endocrine/metabolic (3.8%) comorbidities were most common. The underlying mechanisms among 408 reported comorbidities were, in decreasing order, chance association (42.2%), shared risk factors (31.1%), and causal (26.7%). Experts concluded that it is not uncommon for patients with epilepsy to have comorbidities, and comorbidities reflected differing underlying mechanisms in this population. A worse long-term epileptological outcome was observed in relation to psychiatric, endocrine/metabolic, and respiratory disorders.