Jain RK, et al. - In this retrospective cohort study, researchers assessed risk factors for incident major osteoporotic fractures (MOFs) of the hip, wrist, and humerus in African American (AA), Hispanic (HIS), and Caucasian (CA) patients with diabetes mellitus (DM). The sample consisted of 18,210 patients with DM (7,298 CA, 7,009 AA and 3,903 HIS) at least 40 years of age, being followed at a large healthcare system in Philadelphia, Pennsylvania. In a global model in CA with DM, MOF were linked to dementia, OSA, COPD, and diabetic neuropathy. In AA, MOF were related to prior MOF, dementia, glomerular filtration rate less than 45, thiazide use, metformin use, and chronic steroid use. In HIS, liver disease and insulin use were correlated with MOF. For diabetes patients, both diabetes-specific variables and comorbid conditions are associated with the risk of fracture although these correlations differ by race/ethnicity.