Yoshida M, Minowa K, Amano H, et al. - The present study was performed to explore whether combining maintenance therapy with hydroxychloroquine increases Lupus Low Disease Activity State (LLDAS) achievement rates in individuals with stable systemic lupus erythematosus (SLE). Researchers recruited a total of 30 patients with SLE who visited Juntendo University Hospital who were received maintenance therapy before hydroxychloroquine (HCQ) treatment and were able to complete more than 104 weeks of HCQ treatment. They examined anti-DNA antibody titers, IgG and CH50 levels, the maintenance dose of corticosteroids, the SLE disease activity index, and the achievement of the LLDAS at baseline and at 12, 24, 52, and 104 weeks after HCQ initiation. The outcomes revealed that two years of continuous HCQ treatment led to improvements in SLE disease activity and corticosteroid dose and an increase in LLDAS achievement, thereby indicating the significance of the maintenance dose of HCQ for the management of SLE.