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Combined use of topical intraarticular tranexamic acid and rivaroxaban in total knee arthroplasty safely reduces blood loss, transfusion rates, and wound complications without increasing the risk of thrombosis

BMC Musculoskeletal Disorders Jul 23, 2018

Kim YT, et al. - Authors gauged the simultaneous use of topical tranexamic acid (TXA) and rivaroxaban in total knee arthroplasty (TKA). In patients undergoing TKA, they noted the safety and efficacy of the combined use of intraarticular topical TXA with rivaroxaban to reduce blood loss, the need for transfusion, and wound complications without elevating the risk of deep vein thrombosis (DVT). A significantly higher nadir Hb, lower drain output, Hb decrease, total blood loss, and rate of transfusion and fewer wound complications were seen in the rivaroxaban plus topical TXA (RVTX) group.
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