Liu S, Qiao Y, Zhang Y, et al. - Among the middle-aged and elderly Chinese, this nationwide prospective study was undertaken to investigate if the combination of high depressive symptom burden and hypertension increased the risk of stroke. During 2011–2015, researchers applied data from the China Health and Retirement Longitudinal Study. The final analysis included a total of 12,604 Chinese participants aged 45 years and older. The relationships between high depressive symptom burden, hypertension, and new-onset stroke were explored by using the Multivariate Cox proportional hazards regression model. Among the middle-aged and elderly Chinese, the data imply a combined impact of high depressive symptom burden and hypertension on stroke risk. Adjusted hazard ratios were 1.96 for those with high depressive symptom burden alone, 2.84 for individuals with hypertension alone and 4.38 for individuals with comorbid high depressive symptom burden and hypertension vs those without high depressive symptom burden and hypertension.