Murakami T, Yao T, Yatagai N, et al. - Researchers investigated the clinicopathological features of colorectal adenocarcinoma with enteroblastic differentiation (CAED). They used immunostaining of enteroblastic lineage markers alpha-fetoprotein (AFP), glypican-3 (GPC3), and spalt-like transcription factor 4 (SALL4) for this work. Five CAED cases (0.3%; three patients male and two female) from 1,666 colorectal carcinomas were identified. Findings revealed that the frequent location of CAED was in the sigmoid colon or rectum. It exhibited aggressive behavior, such as lymph node metastasis and distant metastasis, and had a dismal prognosis. Further, CAED was identified immunoreactive to AFP, GPC3 or SALL4, intimating that these markers may be characteristic of CAED.