Madahar P, et al. - Given lung fibrosis is attributed to derangements in extracellular matrix remodeling, a process driven by collagen turnover, researchers performed this cross-sectional analysis to study the association of two collagen biomarkers carboxy-terminal telopeptide of collagen type I (ICTP) and amino-terminal propeptide of type III procollagen (PIIINP), with subclinical interstitial lung disease (ILD) in adults (age 45–84 years) in the Multi-Ethnic Study of Atherosclerosis. They found that higher levels of collagen biomarkers were related to greater high attenuation areas independent of gender, race and smoking status. This finding implied that before the onset of clinically evident disease, extracellular matrix remodeling may accompany subclinical ILD.