Semkovska M, Quinlivan L, O'Grady T, et al. - Researchers investigated cognitive function following a major depressive episode vs normal function. In addition, they determined the pattern and severity of persistent cognitive dysfunctions, and examined how ten prespecified clinical and demographic variables affect these dysfunctions. Searching MEDLINE, Embase, PsycARTICLES, PsycINFO, the Cochrane Library, and relevant reviews identified by the database search, they identified 10,126 citations; of these, the meta-analysis included 75 cognitive variables from 252 eligible studies (11,882 major depressive episode remitters and 8,533 healthy controls). Outcomes revealed the persistence of deficits in selective attention, working memory, and long-term memory in remission from a major depressive episode and their worsening following repeated episodes. They recommend targeting these cognitive functions while treating depression, including relapse prevention, in order to optimize prognosis.