Croall ID, et al. - In an analysis of data from the UK Biobank, researchers studied the prevalence of neuropsychological dysfunction in persons with celiac disease involved in the National UK Biobank, which contains experimental medical data from 500,000 adults in the United Kingdom. Biobank candidates with celiac disease (n = 104; mean age was 63) were matched with healthy people (controls, n = 198; mean age was 63 y) for age, gender, level of education, BMI, and hypertension diagnosis. All individuals were otherwise healthy. Participants with celiac disease had significant deficits in reaction time relative to controls and significantly higher proportions had indications of anxiety, depression, self-harm thoughts, and unhappiness related to health. The authors discovered candidates with celiac disease to have a cognitive deficit, worsened mental health indications, and white matter changes, based on analyses of brain images. Such results support the concept that neurological and psychological characteristics link celiac disease.