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Cognitive decline in older adults: What can we learn from optical coherence tomography (OCT)-based retinal vascular imaging?

Journal of the American Geriatrics Society May 28, 2021

Abraham AG, Guo X, Arsiwala LT, et al. - Researchers assessed the feasibility as well as the utility of employing retinal imaging of microvascular markers to detect older adults at risk of cognitive disease. In the Eye Determinants of Cognition (EyeDOC) study, a biracial, population-based sample of participants was recruited from two sites: Jackson, MS, and Washington Co, MD. Imaging was performed on 976 older adults (mean age of 78.7 (± 4.4) years, 44% black). Infeasibility of performing high-quality optical coherence tomographic angiography (OCTA) scans was evident in nearly half of older adults, in this large biracial community sample of older adults representative of the target population for retinal screening of cognitive risk. Cognitive impairment was not predicted by OCTA markers, among the select sample of healthier older adults with scans.

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