Zanelli J, Mollon J, Sandin S, et al. - Researchers investigated schizophrenia patients following the first episode for cognitive decline, determined if this decline is generalized or confined to individual neuropsychological functions, and assessed if decline is specific to schizophrenia. From a population-based case-control study of patients with first-episode psychosis who were followed prospectively up to 10 years after first admission, they selected patients with a diagnosis of schizophrenia (N = 65) or other psychoses (N = 41) as well as healthy comparison individuals (N = 103) as participants. At index presentation and at follow-up, a neuropsychological battery was administered to the participants. Following illness onset, cognitive decline occurred among patients with schizophrenia and other psychoses, but the magnitude of decline varies across cognitive functions. Declines in IQ and in measures of verbal knowledge and of memory, but not processing speed or executive functions were evident in the schizophrenia group. They observed decline in measures of memory not only among patients with schizophrenia but also among patients with other psychoses. Findings imply a decline as specific to psychosis. Impairments across different cognitive functions seem to be due to distinct mechanisms consequent to the illness and/or psychosocial factors.