Everitt HA, Landau S, O'Reilly G, et al. - In adults with refractory irritable bowel syndrome (IBS), researchers conducted this follow-up study to assess longer-term (24 month) clinical outcomes of telephone cognitive behavioural therapy (CBT) and web CBT vs treatment as usual (TAU). Five hundred fifty-eight adults with refractory IBS were randomly allocated to obtain either therapist-delivered telephone CBT (telephone-CBT group), web-based CBT with minimal therapist support (web-CBT group), or treatment as usual (TAU group) and were followed up for 12 months in the ACTIB three-group, randomised, controlled trial. Sustained improvements in IBS were found in both CBT groups relative to TAU at 24-month follow-up, although some earlier gains compared with 12-month results were decreased. IBS-specific CBT has the ability to provide long-term improvement in IBS that can be accomplished within the usual clinical setting. The long-term patient benefit could be gained by increasing access to CBT for IBS. There have been no treatment-related adverse events.