Goldin PR, Thurston M, Allende S, et al. - Researchers examined if in adults with social anxiety disorder, cognitive behavioral group therapy (CBGT) and mindfulness-based stress reduction (MBSR) induce distinct brain and behavioral effects during cognitive reappraisal and acceptance regulation. They conducted a randomized clinical trial including 108 unmedicated adult participants diagnosed with social anxiety disorder. These adults were randomly assigned to 12 weeks of CBGT, MBSR, or waitlist. Outcomes revealed overlapping and distinct cortical responses in a priori–defined regions of interest for reappraisal and acceptance regulation in correlation with providing CBGT and MBSR. Overall findings revealed that n patients with social anxiety disorder, CBGT and MBSR may result in reduction of clinical symptoms via improving reappraisal and acceptance emotion-regulation brain circuitry.