Malhi GS, et al. - Given a strong association of mood disorders with suicide, the prevention of which is predicated on timely detection of suicidal activity (ideation, behavior), researchers assessed 79 patients with mood disorders clinically and scanned them using fMRI for the nature of neural responses to an emotional-cognitive task. Regions of interest from seven key networks were identified and responses to incongruent stimuli (Happy face-‘Sad’ word; Sad face-‘Happy’ word) were examined. Examination of associations with suicidal activity within the patient group revealed decreased default mode network activity for Happy face-‘Sad’ word manipulation, and increased basal ganglia network activity for Sad face-‘Happy’ word manipulation in those with higher scores, after controlling for patient characteristics. The fMRI findings suggest that in patients with mood disorders, cognitive–emotional deficits may underpin the suicidal activity.