Zhao LG, Li ZY, Feng GS, et al. - In view of the inconsistent results from epidemiological studies on the correlation between coffee intake and cancer risk, researchers sought to summarize and evaluate the quality of the current evidence via performing an umbrella review of existing findings from meta-analyses of observational studies. Searching PubMed, Embase, Web of Science and the Cochrane database, they retrieved 28 individual meta-analyses including 36 summary associations for 26 cancer sites for this umbrella review. Significant associations were evident for five cancers in dose-response analyses. An inverse correlation of coffee intake with the risk of liver cancer and endometrial cancer was observed and this was characterized by dose-response relationships.