Abe SK, et al. - In this pooled analysis, researchers analyzed evidence from eight Japanese cohort studies (144,750 men and 168,631 women) to assess the risk of all-cause and cause-specific mortality among coffee drinkers. They noted an overall protective impact of coffee intake of up to 5 cups/day with respect to all-cause mortality among both men and women, with the association attenuating in the highest category of coffee intake of five or more cups daily. A similar inverse relationship was found among men for major causes of mortality, with the exception of cancer. Mortality risk attributed to heart disease was found to be reduced among women who drank 1–2 cups of coffee per day; however, this risk increased in the ≥ 5 cups/day category. In both sexes, there was no evidence of an association between coffee consumption and cancer. Overall, an attenuated risk of mortality due to major causes may be achieved with coffee consumption under five cups per day.