Mallat SG, et al. – This meta–analysis strived to compare the incidences of cytomegalovirus and BK polyoma virus infections in renal transplant recipients receiving a mammalian target of rapamycin inhibitor (mTOR)–based regimen compared with a calcineurin inhibitor–based regimen. As compared with the calcineurin inhibitor–based regimen, results revealed moderate– to high–quality evidence of reduced risk of cytomegalovirus infection in renal transplant recipients in the mTOR inhibitor–based regimen. Moreover, a combination of a mTOR inhibitor and a reduced dose of calcineurin inhibitor appeared to be associated with similar eGFR and rates of acute rejections and serious adverse events compared with a standard calcineurin inhibitor–based regimen at the expense of higher incidence of proteinuria and wound–healing complications.