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Clinicopathological study of mixed cryoglobulinemic glomerulonephritis secondary to hepatitis B virus infection

BMC Nephrology Sep 18, 2020

Li C, Li H, Su W, et al. - In this retrospective analysis, researchers focused on the clinical characteristics, renal pathology results, as well as prognosis in patients suffering from hepatitis B virus (HBV) related cryoglobulinemic glomerulonephritis (CryoGn). Participants were seven Chinese patients with HBV related CryoGn. At baseline, estimated glomerular filtration rate was 23.5 ml/min per 1.73m2. Purpura (n = 6), arthralgia (n = 1), peripheral neuropathy (n = 1), and cardiomyopathy (n = 1) were documented as extrarenal manifestations. Endocapillary proliferative glomerulonephritis (Gn) (n = 3), membranoproliferative Gn (n = 3), and mesangial proliferative Gn (n = 1) were the renal pathologic revelations on light microscopy. In view of the findings, experts recommend screening the etiology of mixed CryoGn for HBV infection. The common pathologic patterns observed included endocapillary proliferative Gn and membranoproliferative Gn. Renal outcomes were benefited by diagnosis and treatment in early stage. Considering immunosuppressive therapy for severe renal disease was advised, based on efficient antiviral therapy.

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