Ikeda S, et al. - In this investigation involving 106 consecutive patients, researchers assessed the clinical and pathological associations describing each clinical subtype of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Data reported that 55 patients were classified as having typical CIDP. According to findings, preferential participation of distal and proximal segments and uniform pathological characteristics in typical CIDP show a role of humoral factors at sites where the blood-nerve barrier is deficient. By contrast, neuropathic mechanisms that primarily affect the nerve trunk may share focal lesions in multifocal acquired demyelinating sensory and motor, distal acquired demyelinating symmetric (DADS) and pure sensory forms. In cases with marked fascicular variation in myelinated fibre density, epineurial lymphocytic infiltration was conspicuous. In the DADS group, motor conduction velocity was noticeably slowed, and distal motor latencies in the pure sensory group were significantly prolonged.