Bhoyrul B, Asfour L, Lutz G, et al. - This case series describes previously unknown aspects of persistent chemotherapy-induced alopecia (pCIA) in breast cancer patients, including a trichoscopic description. Cosmetically significant regrowth was accomplished in a considerable proportion of patients using topical or systemic therapies, implying that pCIA may be reversible in part.

• Participants in the study were 100 patients (99 women [99%]; mean age at presentation, 54.0 years [range, 29.0-74.1 years]).

• The majority of patients had diffuse nonscarring alopecia (n = 39), female pattern hair loss (n = 55), or male pattern hair loss (n = 6).

• Six patients were diagnosed with cicatricial alopecia.

• Taxane-containing regimens were utilised for the majority of patients (92 [92%]) and were linked to more severe alopecia than non-taxane regimens.

• Trichoscopic findings were indistinguishable from those of androgenetic alopecia in 76 of 86 patients (88%).

• Fourteen of the 18 patients who had biopsies exhibited androgenetic alopecia–like traits, 2 had cicatricial alopecia, and 2 had both.

• Both topical and oral minoxidil, often in combination with antiandrogen therapy, were linked to increased hair density.