Sánchez-Ruano L, et al. - Researchers investigated the clinical utility of peptide microarray technology in food allergy by analyzing studies that have employed B-cell epitopes by peptide microarray in food allergies. Using an established keyword algorithm, they explored PubMed, Web of Science and Embase to identify the relevant studies. They found that among the identified studies, most were cross-sectional (n = 24), incorporated epitope mapping (n = 9), and evaluated diagnostic utility (n = 11). Allergic patients were included in all studies and additional patients (sensitized, persistent, and tolerant) in some. IgE intensity (n = 29), IgG4 intensity (n = 15), and number of peptides (n = 17) were the primary microarray variables examined. According to the findings, clinical reactivity, persistence, severity, or response to oral immunotherapy could be determined by using sensitization to particular epitopes of milk, peanut, and shrimp allergens; however no definitive conclusions can be drawn without addressing critical methodological questions.