Marinelli KC, et al. - Researchers conducted this retrospective cohort study to define the clinical features of late-onset circulatory collapse (LCC) and to explore its correlation with antenatal steroid administration. The sample consisted of infants born ≤ 1,500 g. LCC has been retrospectively diagnosed in infants requiring glucocorticoids for circulatory instability at >1 week of life. Using Mann–Whitney test, demographic and clinical characteristics were compared between groups. Study participants included 310 infants; 19 (6.1%) developed LCC. Infants with LCC have been born at a lower median gestation of 4.6 weeks, 509 g less birth weight than those without LCC. No difference was found in antenatal steroid delivery between the groups. LCC occurs in a distinct subset of VLBW infants, indicating that this high-risk population needs supervision. In this study, antenatal steroids have not greatly increased the risk of developing LCC.