Castellanos LB, et al. - Clinical determinants of intraperitoneal pressure (IPP) variability and the possible association of IPP with peritoneal transport and abdominal wall complications were investigated in peritoneal dialysis (PD) patients. Findings demonstrated that supine IPPs were higher than others published in adults and, IPP had an individual value associated with body size. There was a correlation of greater IPP with lower daily total ultrafiltration (UF) and more hernias and leakages. Notably, IPP measurement is a simple technique, capable of assisting with PD prescription, especially in obese patients.

Methods

• This retrospective, observational study included stable PD patients.
• The Durand's method was used to measure intraperitoneal pressure in supine, sitting, and upright position.

Results

• This analysis included a total of 49 patients; 70% males, mean age 61.1 ± 15 years, body mass index (BMI) 27.9 ± 5.2 kg/m².
• The mean of supine IPP was 18.0 ± 4.4 cm H₂O.
• Researchers noted that intraperitoneal pressure in sitting and upright positions were similar and higher than in supine.
• Data also reported a positive correlation of supine IPP with BMI (p < 0.0005) and comorbidity (p < 0.05).
• It was also revealed in a multivariate linear regression analysis that BMI and comorbidity (p < 0.005) had a positive correlation with IPP; time on PD and daily total ultrafiltration (UF) (p < 0.005) showed a negative correlation.
• In addition, more hernias (35% vs 17%) and leakages (21% vs 8%) were reported in patients with an IPP ≥ 20 cm H₂O, without statistical significance.