Prasad D, et al. - By performing this prospective observational study, researchers examined the link between liver dysfunction, kinetics of liver function tests (LFTs) and severity of hepatitis on the result in pediatric dengue illness. In this study, they examined 102 hospitalized children with dengue infection (66, boys), median age 72 (48–96) months. The most commonly identified abnormality was elevated transaminases (92%); aspartate transaminase in 87% and alanine transaminase in 82%. On day 5 and day 7 of illness, maximum abnormalities in LFTs peaked. Acute liver failure and mortality were independently predicted by the presence of severe hepatitis and shock at presentation, respectively, as revealed using binary logistic regression. Findings revealed liver involvement in many children who had dengue. Significant organ dysfunction and poor outcome were observed in relation to the presence of severe hepatitis in dengue.