Reiff A - In this retrospective review, the researcher assessed referral patterns, clinical presentation, treatment response and long term clinical consequence in a cohort comprising 75 children and adolescents with idiopathic pars planitis (PP) (50), panuveitis (PU) (12) and Vogt–Koyanagi–Harada disease (VKH) (14) followed by the Pediatric Rheumatology Core at Children's Hospital Los Angeles. The participants were observed over an average duration of 52 months. The mean age at disease onset was 10 years and 87% of the patients had bilateral eye involvement. In 21%, 87%, and in 18/75 (24%) of the patients, the presence of glaucoma, vision loss (< 20/40), and legal blindness (< 20/200 or less in the better-seeing eye) was detected at first presentation to an ophthalmologist (PP 22%, PU 36%, VKH 21%). All patients received topical steroids, but additional DMARDs were needed for 98% of the patients and therapy with biologics was needed for 73%. Findings revealed a high risk of permanent vision loss in PP, PU and VKH and early and aggressive management via a skilled rheumatologist was recommended for these conditions.