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Clinical predictors and neural correlates for compromised swallowing safety in Huntington disease

European Journal of Neurology Jun 29, 2021

Schumann-Werner B, Dogan I, Mirzazade S, et al. - By objectively defining dysphagia and swallowing safety in Huntington disease (HD) using fiberoptic endoscopic evaluation of swallowing (FEES) and correlating findings with atrophy patterns revealed by voxel-based morphometry, researchers sought to illustrate pathophysiological mechanisms and neural correlates of dysphagia in HD. Thirty-four HD patients (16 female, Shoulson & Fahn Stage I–IV, two premanifest) had a full clinical–neurological examination including the cranial nerves, the Unified Huntington’s Disease Rating Scale total motor score, and the Mini-Mental State Examination. According to the results, FEES exhibited penetration or aspiration in 70.6%. The findings define dysphagia in HD as a communication disorder between the sensory and motor networks involved in swallowing. This finding, along with the high rates of silent aspiration, supports the use of instrumental swallowing evaluation early in the disease.

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