Chai CS, et al. - Given that the Spanish COPD guideline (GesEPOC) classifies COPD into four clinical phenotypes based on the exacerbation frequency and dominant clinical manifestations, researchers compared the disease-specific health-related quality of life (HRQoL) of patients with different clinical phenotypes. The study sample consisted of patients with COPD attending the respiratory medicine clinic of University of Malaya Medical Centre from June 1, 2017, to May 31, 2018. Of 189 patients, 28.6% had a non-exacerbator phenotype (NON-AE), 18.5% had exacerbator with emphysema phenotype (AE NON-CB), 39.7% had exacerbator with chronic bronchitis phenotype (AE CB), and 13.2% had asthma-COPD overlap syndrome phenotype (ACOS). The results obtained from the cross-sectional study indicate that patients who were AE CB had significantly lower HRQoL than other clinical phenotypes and each of the COPD Assessment Test (CAT) items and St George’s Respiratory Questionnaire for COPD (SGRQ-c) components recorded the worst score. AE CB patients can, therefore, warrant a different approach to treatment that focuses on the components of exacerbation and chronic bronchitis.