Toyoda K, et al. - In this exploratory analysis of the ATACH-2 (Antihypertensive Treatment in Intracerebral Hemorrhage 2) data, researchers assessed if clinical outcomes and acute systolic blood pressure (SBP) levels achieved following intracerebral hemorrhage (ICH) were linked. Eligible patients randomized to the ATACH-2 trial were divided into five groups by 10-mmHg strata of average hourly minimum SBP (<120, 120–130, 130–140, 140–150, and ≥ 150 mmHg) for 2 to 24 hours following randomization. The positive correlation of SBP levels with modified Rankin Scale (mRS) 4 to 6 at 90 days was seen only between the average minimum SBP of the 120- to 130-mmHg group and 140- to 150-mmHg group. The 140 to 150 and ≥ 150 groups displayed a lower frequency of the events than the 120 to 130 group. Cardiorenal complications offset the beneficial effects of reducing and maintaining SBP in the first 24 hours at 120 to 130 mmHg (by suppressing hematoma expansion) on clinical outcomes somewhat.