Clinical, microscopic and molecular presentation in pediatric vs adult old world cutaneous leishmaniasis
Pediatric Dermatology May 22, 2020
Dunya G, Loya A, Taraif S, et al. - Researchers sought to evaluate various clinical, microscopic, and molecular aspects of cutaneous leishmaniasis (CL) in pediatric patients in this large multiregional cohort. In addition, they compared childhood and adult CL. In total, 382 individuals from Lebanon, Saudi Arabia, Pakistan, and Syria diagnosed with CL by punch biopsy/scrapings were grouped into adults (> 18 years) and pediatrics (≤ 18 years). The data reported included clinical characteristics [number, location, type, size, and extensiveness (size larger than 3 cm, more than 5 lesions per patient, lesion present for more than 12 months, special types, disfiguring lesion or closeness to vital sensory organs) of lesions] and microscopic findings [Ridley's Parasitic Index and Ridley's Pattern]. Molecular confirmation and speciation were also performed. The pediatric group had a higher number of lesions, more involvement of the head and neck, more extensive illness and more advanced lesions. Microscopically, a more advanced Ridley's pattern has been found. CL has historically been known to be a neglected tropical disease of poverty and pediatric predilection. CL presents in the pediatric group with more extensive disease clinically represented microscopically by more advanced lesions.
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