Yoshida N, Kosumi K, Tokunaga R, et al. - Researchers performed this study among 570 patients with esophageal cancer who underwent radical esophagectomy, to assess the clinical utility of mean corpuscular volume (MCV) for prognostic prediction in this patient population. Two groups of patients were defined based on the standard value of pretreatment MCV: normal (83–99 fL) and high (> 99 fL) groups. A significant link of high MCV with lower body mass index, higher frequency of habitual alcohol and tobacco use, and a higher incidence of multiple primary malignancies other than esophageal cancer, was revealed. The correlation of high MCV, with a higher incidence of postoperative morbidity of the Clavien–Dindo classification ≥ II and pulmonary morbidity, was evident. Patients with high MCV experienced significantly worse overall survival. In multivariate analysis, high MCV was identified as an independent risk factor for worse survival outcome. Findings revealed the presence of several disadvantages in the clinical background among patients with high MCV, and these disadvantages can have an adverse influence on both short- and long-term results post-esophagectomy. Findings are also indicative of the ability of MCV to serve as a predictive marker for the estimation of survival outcome following esophagectomy for esophageal cancer.