Shor N, Aboab J, Maillart E, et al. - Researchers characterized the clinico-radiological phenotype as well as the result of patients with myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-related optic neuritis (ON). For this purpose, they reviewed records of 62 adult patients who were admitted in three medical centres and had orbital and brain MRI done at the acute phase. They also reviewed spinal cord MRI within 1 month from the ON as well as all of the follow-up MRI. The presence of bilateral ON and optic disc swelling was noted in 41.9% and 66.2% of the patients, respectively. Initial MRI revealed lesions that were anterior (92%), extensive (63%) and related to optic perineuritis (46.6%). Overall 51.8% of patients had silent brain lesions, but were principally non-specific (81%). The last follow-up revealed visual acuity ≤ 0.1 in 5% of patients. No alteration on brain MRI was seen in 41 patients (87%). Experts concluded that MOG-IgG-associated ON mostly runs a benign ophthalmological course, although the presence of initially longitudinally extensive lesions, as well as the development of optic nerve atrophy on orbital MRI, were evident. In the identification of silent suggestive lesions, spinal MRI could be of interest.