Dirlikov E, et al. - Researchers attempted to identify specific clinical features of Guillain-Barré syndrome (GBS) associated with Zika virus (ZIKV) infection. Prospective and retrospective strategies were used to identify patients with GBS who had neurologic illness onset in 2016 and were hospitalized at all 57 nonspecialized hospitals and 2 rehabilitation centers in Puerto Rico during the ZIKV epidemic in Puerto Rico. Using the Brighton Collaboration criteria, Guillain-Barré syndrome diagnosis was confirmed via medical record review. Data reported that GBS associated with ZIKV infection was found to have higher morbidity during the acute phase and more frequent cranial neuropathy during acute neuropathy and 6 months afterward. Results show GBS pathophysiologic mechanisms that might be more common after ZIKV infection.