Clinical factors, diagnostic delay, and residual deficits in chronic inflammatory demyelinating polyradiculoneuropathy
Journal of the Peripheral Nervous System Sep 22, 2019
Bunschoten C, et al. - Researchers undertook this cross-sectional analysis in the Netherlands, to know about the contemporary practice of diagnosis and treatment in relation to the clinical consequence of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Overall 112 patients had a confirmed diagnosis of CIDP. As far as the time from the start of symptoms until CIDP diagnosis was concerned, it was median 5 months and > 12 months in 26% of the patients. Another initial diagnosis, multifocal abnormalities, final diagnosis made in university hospitals, and more (residual) complaints were more frequently seen in patients with a late diagnosis (> 5 months) vs those with early diagnosis (≤ 5 months). Despite receiving treatment by 97% of patients, neurological symptoms and deficits were reported by 88%. Findings revealed that CIDP diagnosis was usually delayed, particularly in cases with atypical CIDP variants. The treatment commencement may be delayed because of a diagnostic delay. In CIDP, residual neurological deficits and accompanying disability may be prevented or at least attenuated via a more rapid and accurate diagnosis of CIDP.
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