Bogoch II, et al. - In view of the findings that soil-transmitted helminths (Ascaris lumbricoides, hookworm, Strongyloides stercoralis, and Trichuris trichiura) have infected more than 1.5 billion people, researchers performed a longitudinal clinical evaluation of school-age children to determine the relationship between soil-transmitted helminth infection, adverse health outcomes, and the advantageous impacts of deworming. Embedded into a randomized controlled trial, this study assessed 434 children 7–14 years old, via their medical history, a physical examination, stool microscopy for soil-transmitted helminths, and hemoglobin (Hb) measurement at baseline. At 3 and 18 weeks posttreatment, they repeated an assessment of medical history and stool examination. Repeated Hb measurement was also done at the 18-week treatment follow-up. Infestation with T. trichiura was identified in all enrolled children, and they were randomized into four different treatment interventions. None of the findings of the other assessments were related with A. lumbricoides, hookworm, or S. stercoralis infection at baseline. Findings revealed a weak correlation between morbidity and soil-transmitted helminth infection, as there was a small tendency toward improving Hb values following the treatment of hookworm infection. This study illustrates the difficulties of determining morbidity related to soil-transmitted helminth infection and treatment, thus establishing the mainly subtle morbidity effects of infection.