Kunutsor SK, et al. - A systematic review and meta-analysis were carried out to correlate the clinical effectiveness of various treatment strategies for infected ankle prostheses. Researchers performed to search MEDLINE, Embase, Web of Science, and the Cochrane Library up to December 2018 for studies evaluating the effect of treatment in patient populations with infected ankle prostheses following total ankle replacement. They pooled binary data after arcsine transformation. This study included citations comprising 17 observational design comparisons. The results showed that one- and 2-stage revision strategies are correlated with the lowest reinfection rates, but these findings are based on limited data. For the treatment of infected ankles prosthesis, arthrodesis and debridement and implant retention with or without polyethylene exchange seem to be commonly applied but are correlated with poor infection control. Clear gaps exist in the literature, and future study is needed to assess treatment strategies for infected ankle prosthesis.