Prins KW, et al. - In this cohort study, researchers explored the associated features and clinical implications of right ventricle (RV) dysfunction in 147 patients with pulmonary hypertension caused by chronic lung disease (Group 3 PH). They used right ventricular fractional area change (RVFAC) and ⁺dP/dt_max/instantaneous pressure to quantify RV systolic function. RV diastolic function was characterized by tau and RV diastolic stiffness. On univariate analysis, pulmonary arterial compliance, cardiac index, and left ventricular diastolic dimension were identified as positive correlates of RVFAC, while negative correlates included male sex, N-terminal pro-brain natriuretic peptide, heart rate, right atrial enlargement, mean pulmonary arterial pressure, and pulmonary vascular resistance. In Group 3 PH and even after adjusting for RV afterload, male sex was found to be related to RV dysfunction. Group 3 PH patients at risk for poor outcomes were identified by RV dysfunction (RVFAC <28%).