Hart SE, Brown DL, Kim HM, et al. - Among women receiving implant-based or autologous breast reconstruction, no higher likelihood of complications was observed in the setting of neoadjuvant or adjuvant chemotherapy, and there was no significant impact of chemotherapy status on satisfaction with reconstruction or psychosocial well-being.

• This cohort study included 1881 women undergoing breast reconstruction.

• The BREAST-Q questionnaire was applied to assess complications and patient-reported outcomes.

• Among participants, implant-based procedures were received by 1373 (73.0%), and autologous reconstruction, neoadjuvant chemotherapy, adjuvant chemotherapy and no chemotherapy was received by 508 (27.0%), 200 (10.6%), 668 (35.5%), and 1013 (53.9%), respectively.

• Among participants receiving implant-based reconstruction, significantly different rates of any complication were identified, with higher rates observed for adjuvant and neoadjuvant chemotherapy vs no chemotherapy.

• Multivariable analysis showed these differences were not statistically significant.

• No significant differences in complications were found for autologous reconstruction.